https://www.ceesdekker.net Secrets

https://www.ceesdekker.net Secrets

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Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions incorporate:

Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular sorts with recombination perform.

Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins

Our operate was promptly adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors made from single- and multi-walled carbon nanotubes in Utilized Physics Letters.

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time research of your dynamics DNA supercoils and the invention of supercoil hopping

Direct immobilization of native yeast iso-1 cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-film voltammetry

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which evaluate the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives include things like the subsequent:

Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, plus a 3D rendering of the motion of your DNA rod is shown.

The rotors harness Power from the nanoscale drinking water and ion movement that is produced by a static chemical or electrochemical prospective gradient in the nanopore, which might be proven through a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting strategies to constructing Electricity-transducing motors at nanoscale interfaces.

But carbon nanotubes have remained a exploration matter of significant curiosity to several. Certainly, the outlook on utilizing carbon nanotubes to build practical equipment, in spots which include radio-frequency electronics, electronic electronics and flexible electronics, remains dazzling.

FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division

2006, very first demonstration of molecular sorting in a very lab on a chip making use of biomotors; discovery of nanobubbles in stable-point out nanopores; and initial estimate of electrokinetic Strength conversion in a very nanofluidic channel

Visualization of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy approaches

Solid-condition https://www.ceesdekker.net nanopores have established to become a incredibly adaptable probe for solitary-molecule Evaluation of DNA. I will describe some of our recent conclusions – precisely DNA knots – and our initiatives to develop the abilities of sound-state nanopores even additional, in the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.